Dysregulating the regulators
نویسندگان
چکیده
منابع مشابه
Dysregulating the regulators
Two articles in this issue of Journal of Biology prompt a brief reflection on the regulation of adaptive immune responses. (I suspect many, if not most, non-immuno-logical readers may find immunology impenetrable, and I cannot promise that what follows will reassure them, so they may like to click over to something else – Articles by Semple on diabetes [1], or Garfield and Wray on the evolution...
متن کاملThe PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.
The identification of mutations in PTPN11 (encoding the protein tyrosine phosphatase Shp2) in families with congenital heart disease has facilitated mechanistic studies of various cardiovascular defects. However, the roles of normal and mutant Shp2 in the developing heart are still poorly understood. Furthermore, it remains unclear how Shp2 loss-of-function (LOF) mutations cause LEOPARD Syndrom...
متن کاملRegulating the regulators
According to a modest estimation, one third of the known eukaryotic proteins can be phosphorylated. Protein kinases are members of a large superfamily and incorporate the phosphate moiety into the serine (Ser), threonine (Thr) or tyrosine (Tyr) residues of their target proteins. In comparison, protein phosphatases are less numerous but more diverse. They can be classified into four independent ...
متن کاملDabigatran, bleeding, and the regulators.
Dabigatran was the first drug across the finish line in the global race to develop a new and better replacement for the five decade old anticoagulant warfarin. An important indication was long term treatment to reduce the risk of stroke in patients with non-valvular atrial fibrillation. This vulnerable older group, mostly over age 75, number many millions worldwide. The main risk of treating at...
متن کاملThe TetR family of regulators.
The most common prokaryotic signal transduction mechanisms are the one-component systems in which a single polypeptide contains both a sensory domain and a DNA-binding domain. Among the >20 classes of one-component systems, the TetR family of regulators (TFRs) are widely associated with antibiotic resistance and the regulation of genes encoding small-molecule exporters. However, TFRs play a muc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biology
سال: 2009
ISSN: 1475-4924
DOI: 10.1186/jbiol175